Brenda Goldstein graduated from the Ontario College of Art and Design in 2001 and has received several awards, including the William F. White Prize for excellence in film production, the Charles Street Video Prize, both in 2001, and the Ontario Arts Council Emerging Artist Award for Film and Video in 2005.

Her work has been exhibited in galleries and at festival across Canad and the U.S. including the 2008 World Wide Short Festival (Toronto); Herland Film Festival (Calgary, 2006); Planet in Focus Festival (Toronto, 2005); Images Festival (Toronto, 2005); and at the PDX Film Festival (Portland, Oregon, 2004). In 2006, her work was included in Atchung, Baby, a program of performance videos curated by artists Johanna Householder and Nina Czegledy. The program traveled to venues in Slovakia, Hungary and Romania. 

In spring 2006, she curated The Centre Cannot Hold at the Toronto Free Gallery (April - June 2006) and in 2007 she joined the gallery's Board of Directors. She currently coordinates a locative media research project at the Ontario College of Art and Design, and is a member of the Toronto curatorial collective, Pleasure Dome.